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抗CCP抗体在RA诊断与判断预后中的作用
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下一篇 2012-02-02 22:21:49
/ 个人分类：类风湿关节炎专题
抗CCP抗体在RA诊断与判断预后中的作用
徐宁
摘要：环瓜氨酸多肽抗体(ACPAs)是2010ACR/EULAR 类风湿关节炎分类标准中的第二个血清学标志，主要应用于早期诊断与治疗。本篇文章主要讨论了ACPAs研发历史以及临床应用情况。尤其是重点讨论了ACPAs作为类风湿关节炎的诊断标志物与传统的类风湿因子比较具有更重要的诊断价值。同时，本文也旨在提高医生对于ACPAs家族其他成员，如anti-Sa/anti-MCV的关注与兴趣。anti-Sa/anti-MCV在研究中显示出比anti-CCP 或 RF对于类风湿关节炎患者的疾病活动度以及治疗效果有更好的相关性。
附原文：Abstract Antibodies to citrullinated proteins/peptides (ACPAs) are the second serological marker to have recently been included in the 2010 ACR/EULAR Rheumatoid Arthritis (RA) Classification Criteria, which are focused on early diagnosis and therapy. This review discusses their history and some clinical aspects of ACPAs, focusing on the diagnostic utility of anti-cyclic citrullinated peptide (anti-CCP) antibodies as a marker of RA as compared to the widely used rheumatoid factor (RF). Simultaneously, this review aims to raise physician awareness and interest in anti-citrullinated vimentin antibody (anti-Sa/anti-MCV), another member of the ACPA family, which appears to have a better predictive value as a marker of RA than anti-CCP or RF and correlates closely with disease activity and therapeutic response among patients with RA.
引自：Role of anti-citrullinated protein antibodies in diagnosis and prognosis of rheumatoid arthritis. Arch Med Sci. 2011 Apr;7(2):189-94. Epub 2011 May 17.
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