以“解答疑难，探讨学术，展示风采，开创未来”为宗旨。建议：点击上方“日志”或“图片”，有大量精彩内容供参考！点击“留言”，可解答疑问，但稳妥解决问题仍需就诊。科室成员的“好大夫网站”(http://liuxiangyuan.haodf.com，http://yaozhongqiangdr.haodf.com，http://dearnesta.haodf.com/，http://zhaojinxia.haodf.com)及医院网站(http://www.bysy.edu.cn/fsmyk/index.shtml)有出诊时间、网络预约挂号、预约电话咨询及解答疑难！
富含巨糖肽和G600奶脂的脱脂奶粉可降低痛风复发率
上一篇 /
下一篇 2012-02-02 08:49:53
/ 个人分类：痛风专题
富含巨糖肽和G600奶脂的脱脂奶粉可降低痛风复发率
姚中强
摘要（新西兰）: 目的 前期急性痛风动物模型研究发现，两种主要成分巨糖肽和G600奶脂提取物有抗炎作用。本试验目的是验证富含巨糖肽和G600奶脂提取物的脱脂奶粉是否可减少痛风复发率的假说。
方法: 为期3个月的随机双盲对照试验。120名复发性痛风患者随机分为3组：乳糖奶粉对照组，脱脂奶粉（SMP）对照组和富含巨糖肽和G600奶脂提取物的脱脂奶粉组(SMP/GMP/G600)。原发终点为痛风复发率的改变。
结果 与基线相比，三个试验组患者的痛风复发率在3个月的实验期间均有下降，SMP/GMP/G600组痛风复发率下降更为显著(卡方检验p(组间)=0.031, 与乳糖对照组相比，Tukey post hoc 检验的p=0.044)。 SMP/GMP/G600 治疗3个月后，疼痛、尿酸排泄率也有显著改善，压痛关节数也有改善趋势，三组间不良反应和脱组率相仿。
结论: 本实验为对痛风患者食物干预治疗的首次报道，提示富含巨糖肽和G600奶脂提取物的脱脂奶粉可降低痛风患者的复发率。
附原文: Abstract OBJECTIVES: Previous laboratory studies have identified two dairy fractions, glycomacropeptide (GMP) and G600 milk fat extract (G600), with anti-inflammatory effects in models of acute gout. The aim of this proof-of-concept clinical trial was to test the hypothesis that daily intake of skim milk powder (SMP) enriched with GMP and G600 can prevent gout flares. METHODS: This was a 3-month randomised double-blind controlled trial of milk products for prevention of gout flares. One hundred and twenty patients with recurrent gout flares were randomised to one of three arms: lactose powder control, SMP control and SMP enriched with GMP and G600 (SMP/GMP/G600). The primary end point was change in the frequency of gout flares using a daily flare diary measured monthly for 3 months. RESULTS: The frequency of gout flares reduced in all three groups over the 3-month study period compared with baseline. Over the 3-month study period there was a significantly greater reduction in gout flares in the SMP/GMP/G600 group (analysis of covariance p(group)=0.031, Tukey post hoc test compared with lactose control, p=0.044). Following treatment with SMP/GMP/G600 over the 3-month period, greater improvements were also observed in pain and fractional excretion of uric acid, with trends to greater improvement in tender joint count. Similar adverse event rates and discontinuation rates were observed between the three groups. CONCLUSIONS: This is the first reported controlled trial of dietary intervention in patients with gout, and suggests that SMP enriched with GMP and G600 may reduce the frequency of gout flares.
引自： Dalbeth N, Ames R, Gamble GD, Horne A, Wong S, Kuhn-Sherlock B, Macgibbon A, McQueen FM, Reid IR, Palmano K. Effects of skim milk powder enriched with glycomacropeptide and G600 milk fat extract on frequency of gout flares: a proof-of-concept randomised controlled trial. Ann Rheum Dis. 2012 Jan 23. [Epub ahead of print]
有关视频报道见：http://www.t-d.tv/Play/2012-2-3/ebc6492056aa49c1960f3a5b945e0bd1
导入论坛
收藏
分享给好友
推荐到圈子
管理
举报
TAG:
动物
奶粉
痛风
