1.完全了解纤维肌痛需认真评估疼痛、功能和心理情境。纤维肌痛应被认为是一种复杂和异质的状况,有异常疼痛处理过程和其他继发性特征。
2.最佳治疗需多学科处理,根据患者疼痛强度、功能和相关特征如抑郁、疲乏和睡眠障碍,联合药物和非药物治疗。
3.个性化锻炼项目包括有氧锻炼和肌力训练对某些患者有益
4.认知行为治疗可能对某些患者有益处
5.热水池(有或无锻炼)对纤维肌痛综合症是有效的
6.抗抑郁药阿米替林(amitriptyline)、氟西汀(百优解,fluoxetine)、度洛西汀(duloxetine),盐酸米那普仑(milnacipran)、吗氯贝胺(moclobemide)和吡扎地尔(pirlindole)可减轻疼痛并常可改善功能,可用于治疗纤维肌痛综合症。
7.曲马多推荐用于纤维肌痛的疼痛处理。
8.托烷司琼(呕必停,Tropisetron)、普拉克索(pramipexole)和普瑞巴林(pregabalin)可减轻疼痛,可治疗本病。
9.根据每个患者的需要,可使用其他治疗如松弛、康复、体疗和心理支持。
1.Full understanding of fibromyalgia requires comprehensive assessmentof pain, function and psychosocial context. Fibromyalgia shouldbe recognised as a complex and heterogeneous condition wherethere is abnormal pain processing and other secondary features.
2.Optimal treatment requires a multidisciplinary approach witha combination of non-pharmacological and pharmacological treatmentmodalities tailored according to pain intensity, function, associatedfeatures, such as depression, fatigue and sleep disturbancein discussion with the patient.
3.Individually tailored exercise programmes, including aerobicexercise and strength training can be beneficial to some patientswith fibromyalgia.
4.Cognitive behavioural therapy may be of benefit to some patientswith fibromyalgia.
5.Heated pool treatment with or without exercise is effective in fibromyalgia
6.Antidepressants: amitriptyline, fluoxetine, duloxetine, milnacipran, moclobemide and pirlindole, reduce pain and often improve function therefore they should be considered for the treatment of fibromyalgia
7. Tramadol is recommended for the management of pain in fibromyalgia
8.Tropisetron, pramipexole and pregabalin reduce pain and should be considered for the treatment of fibromyalgia
9.Other therapies such as relaxation, rehabilitation, physiotherapyand psychological support may be used depending on the needsof the individual patient.
(S F Carville,S Arendt-Nielsen,H Bliddal,et al.EULAR evidence based recommendations for the management of fibromyalgia syndrome.Annals of the Rheumatic Diseases,2008;67:536-541)